Abstract
activity of pituitary preparations was first demonstrated by KETOGENIC Burn and Ling (i). Further investigations have shown that heat treat‘ment in an alkaline medium inactivates such preparations, and Shipley and Long have reported on the complete inactivation of ketogenic potency follow ing heat treatment (2, 3). We recently pointed out (4) that, in a previous communication (5), in which it was shown that ketonemia could be pro‘ duced by certain extracts which had been heat treated in an aqueous alka‘line medium, we had not sufficiently stressed the fact that by far the major part of ketogenic activity present in the original extract had been removed by the fractionation procedure. In the experiments which are now reported it is shown that the major part of the ketogenic activity in anterior lobe extracts is present in the protein fractions, and that in the case of most of these boiling in dilute acid medium does not remove the ketogenic property.
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