Abstract
The effect of Pitressin on the renal response to a salt load was studied in normotensive and hypertensive rats. Hypertension was induced by DCA, Compound F, or renal compression. Renal function under load was studied by administering inulin together with a salt load. The effect of 2 I.U. of Pitressin given subcutaneously was studied at two periods, 45 min. and three hours after injection. The first phase of Pitressin action was characterized, as before, by an increase in the excretion of sodium and water. While this was qualitatively similar in all experiments, the degree of response varied greatly, being least evident in rats with Compound F hypertension. The data indicate that a large increase in excretion involves a decrease in the tubular reabsorption of sodium and water. The second phase of Pitressin action was characterized, as before, by conspicuous sodium and water retention. This retention can be explained as a reflection of changes in the filtered load which might in turn be due to a change in renal hemodynamics or to a minor decrease in plasma sodium and water.
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