The Effect of Pioglitazone on Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, Tumor Necrosis Factor-α, Vascular Endothelial Growth Factor and E-Selectin in Skin Lesions in Psoriatic Patients with and without Psoriatic Arthritis

Abstract

Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. The aim of the present study was to investigate the role of MMP-9 in the development of psoriasis by assessing the presence of MMP-9 in lesional skin and in sera of psoriatic patients with & without psoriatic arthritis, the association of MMP-9 with the activity of the disease, the relationship between MMP-9 and TNF-