Abstract
The transport of CO2 from tissue is influenced by oxygen through changes in tissue blood flow and in the magnitude of the Haldane effect, even when the arterial CO2 tension is kept constant. The increase in ventilation following hyperbaric O2 breathing, seen in human beings, has been ascribed to the increase in CO2 tension at the central chemosensitive structures which results from these effects of O2 on CO2 transport (Lambertsen et al., 1953). In this paper we develop a simple mathematical model for CO2 transport from tissue which incorporates the influences of O2 on CO2 transport. The changes in CO2 tension due to the reduction of the Haldane effect by physically dissolved O2 during hyperoxia are calculated and compared with measurements of venous and cerebrospinal fluid CO2 tensions.
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