The effect of photodynamic therapy with pheophorbide-a on chemically induced papillary skin lesions in hairless mice

Abstract

Photodynamic therapy (PDT) is an alternative treatment option for early stage oral cancer and precancerous lesions due to the limitations of conventional treatment modalities. Pheophorbide a (Pa) is a chlorine-based photosensitizer extracted from chlorophyll-a, which is known to be activated by light at a wavelength of 670nm, is rapidly metabolized, and is selectively accumulated in tumor cells over a longer duration. The aim of this study is to validate the antitumor efficacy of PDT after the injection of Pa in murine papillary skin lesions.