Abstract
Abstract Male fern extract has earlier been shown to produce Bromsulphalein (BSP) retention and increased serum bilirubin in humans. Out of 19 pure substances from male fern tested, four were found to cause BSP retention in rabbits. These four substances have certain details in their chemical structure in common. One of them, flavaspidic acid, was studied in detail, using a dose of 0.02 mmole per kilogram. Its action on BSP retention was found to commence immediately after intravenous injection and to last for 9 to 16 hours. It also caused retention of rose bengal and bilirubin. Studies on the different steps in dye excretion (uptake, conjugation, secretion) with the use of BSP in rats and radioactive rose bengal in rabbits showed that the action was exerted on the uptake of dye by the liver cell. The mechanism for this action may be a reversible competitive inhibition of binding of the dyes to cellular proteins.
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