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Abstract
Abstract— A mitochondrial fraction isolated from the cerebral cortex of immature rats was shown to possess the characteristics of intact, functional mitochondria. Phenylpyruvate, in low concentrations, had an inhibitory effect upon oxygen utilization by this system without uncoupling phosphorylation. The inhibition was specific for the keto acid and to pyruvate as substrate. It was concluded that phenylpyruvate inhibits the oxidation of pyruvate and the implications of this are discussed in relation to phenylpyruvic oligophrenia.
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