Abstract
The effects of phenothiazine and non-phenothiazine inhibitors of calmodulin on ATP-dependent calcium transport by a microsomal fraction from human platelets have been studied. Trifluoperazine, chlorpromazine, and zinc inhibited calcium transport in a dose dependent fashion. The dose required for half-maximal inhibition of calcium uptake was 16 uM, 19 uM, and 130 uM, respectively. Chlorpromazine sulfoxide and other divalent cations had no effect on calcium uptake. Neither trifluoperazine nor zinc caused efflux of calcium from preloaded microsomes indicating that their effect on calcium accumulation was on the influx of calcium. Chlorpromazine affected both influx and efflux of calcium. These results implicate calmodulin in calcium transport by the platelet microsomal fraction.
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