Abstract
The effect of PGI 2 analogues with increased stability at a physiological pH on the aggregation and intracellular cAMP content of platelets were investigated. The ethyl ester derivative of PGI 2 and its complexes with β-cyclodextrine proved to be more stable than the sodium salt of PGI 2. The stimulation of adenylcyolase positively correlated with their inhibitory effect on platelet aggregation.
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