Abstract
We compared the effect of tropical application of PGF 2a on cerebral arterioles in cats and rats equipped with an acutely implanted cranial window. Arterial diameter was measured using a microscope and image splitting device. PGF 2a in a concentration ranging from 10 −7 to 10 −5 M had no effect on large (≥ 100 μm) or small (< 100 μm) cat pial arterioles, but induced a dose dependent constriction of rat pial arterioles with a maximum constriction fo 76% of control diameter. Dilation of cat large cerebral arterioles by topically applied PGE 2 was not affected by simultaneous application of PGF 2a and PGE 2 induced dilation of small arterioles was decreased 3% by PGF 2a. While we and others have previosuly shown that both cat and rat brain can synthesize PGF 2a, it appears that PGF 2a is not likely to normally be a major modulator of cerebral arteriolar resistance in all species.
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