The Effect of Peri-Implant Disease on Oxidative Stress Markers Levels in Peri-Implant Sulcus Fluid: A Cross-Sectional, Pilot Study

Abstract

Background: Peri-implant diseases are inflammatory diseases as periodontal disease. An array of oxidative stress markers has been examined in the disease and health of the periodontal tissues. The purpose of the study was to test whether peri-implant conditions have an impact on the peri-implant sulcus fluid oxidative stress markers.Materials and Methods: A total of 44 participants were included in the study. Collected samples divided 3 groups, 14 samples for healthy implants; 15 samples for peri-implant mucositis; and 15 samples for peri-implantitis. In clinical periodontal examination, plaque index (PI), modified bleeding index (mSBI), probing bleeding (BOP), probing pocket depth (PPD), gingival index (GI), modified plaque index (MPI) were measured. Peri-implant sulcus fluid (PISF) samples were collected for evaluating and measuring biochemical analysis of total oxidant status (TOS) and total antioxidant capacity (TAOC) and oxidative stress index (OSI).Results: The TOS level in PISF was statistically significantly higher in the peri-implantitis when compared to the healthy group (p=0.041). There was no statistically significant difference (p>0.05) between groups in terms of TAOC and OSI parameters.Conclusions: As a result of the current study, it can be said that, due to its inflammatory character, peri-implantitis can increase total oxidant status (TOS) in peri-implant sulcus fluid (PISF). Multicentered research is needed to explain which immunological mechanism triggers the oxidative system in peri-implantitis in order to understand the potential role of oxidative stress markers in peri-implant inflammation.