Abstract
To create awareness for mismeasurements of ion-selective electrodes caused by patients' medications and to prevent severe consequences in an intensive care therapy. A 73-year-old woman presented with severe carbimazol-induced toxic epidermal necrolysis. After replacement of carbimazol by sodiumperchlorate, we detected a huge discrepancy in the measurement of ionised calcium by two different Point-of-Care (POCT) systems. While Siemens Rapidlab 865 showed a severe hypocalcemia at all times, the Radiometer 600 system first presented a severe hypercalcemia and, in the course of the following days, also a hypocalcemia but with significantly (p < 10 to the -45) higher values than the Rapidlab system. Furthermore, the POCT systems detected a pseudohypocalcemia at times where we think there was a normo- or even hypercalcemia which led to incorrect therapy with excessive substitution of ionised calcium. The substance sodiumperchlorate, which is well established in Europe for hyperthyreosis therapy, caused malfunctions of analyses of ionised calcium by POCT systems.
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