Abstract
The effect of various doses of pentylenetetrazol (PTZ) on the levels of dopamine-β-hydroxylase (DβH) and acetylcholinesterase (AChE) in the CSF of rabbits was studied. The drug augments in a dose-dependent manner the DβH activity but causes only a small and dose-independent increase in AChE. This suggests that PTZ-induced convulsions are associated with an increase in central noradrenergic activity but not by an increase in central cholinergic activity.
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