Abstract
Abstract The effect of finely divided silica on the antifoaming properties of polydimethylsiloxanes (dimethicone 1000) when formulated in a typical antiflatulent tablet has been examined. A dynamic froth test has been used to show that removal of extractable dimethicone by ether extraction of the tablet powder markedly reduces the antifoaming properties of the powder, despite retention of a small percentage of the polydimethylsiloxane dispersed on the surface of the silica and aluminium hydroxide gel content of the tablet. A series of static froth tests similarly demonstrate that tablet formulations from which silica is omitted also possess significant antifoaming properties.
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