Abstract
Summary 1. The effect of parathyroid hormone on respiration and ion transport in the terminal portion of the electron transport chain has been studied using rat-liver mitochondria. Ascorbate and N,N,N′,N′ -tetramethyl- p -phenylenediamine were employed as electron donors to cytochrome c . 2. P/O ratios near 1.0 were obtained with the system in the absence of hormone. Addition of parathyroid hormone caused an uncoupling of phosphorylation and respiration. 3. The hormone was shown to stimulate mitochondrial respiration and the accumulation of phosphate, magnesium and potassium ions. 4. Some aspects of the action of the hormone are contrasted with those of valinomycin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
