Abstract
The effects of paraquat treatment (10 mg/kg, i.p.) on the guanylate cyclase activity in relation to the occurrence of morphological changes were examined in guinea pig lungs. It was found that paraquat-treated animals, as compared to controls, had a marked activation of guanylate cyclase activity and varying degrees of progressively advancing histopathological changes in the lung. A marked activation in guanylate cyclase activity preceding the development of pulmonary fibrosis in paraquat-treated animals supports the hypothesis that an increased level of intracellular cyclic GMP may somehow be involved in the fibroproliferative changes that eventuate in pulmonary fibrosis.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
