The effect of pacitan’s sweet orange’s (Citrus sinensis (L.) osbeck) peel powder on the lipid profile of male dyslipidemia rats (Rattus novergicus)

Abstract

Introduction: Dyslipidemia is a lipid metabolism disorder characterized by the increasing TC, LDL cholesterol, triacylglycerol TG above normal values and a decrease of HDL in the blood. Increasing LDL-C and triacylglycerol have a correlation with poor cardiovascular circumstances, and increased lipid absorption may lead to conditions of dyslipidemia. Orange peel is often considered a waste that is not useful. The purpose of this study wanted to know the effect of giving orange peel to the mice dyslipidemia. Methods: This study was an experimental study, using a randomized post test only control group design using twenty-seven white rats (Rattus norvegicus) Wistar strains. This study lasted for eight weeks. Mice dyslipidemia is made by giving high-fat feed to all groups of K1, K2, and K3. Each group consists of 9 white rats divided randomly. The composition of high-fat feed is a modification of the formula Nutrient requirements of laboratory animals. Results: The mean of body weight of K1, K2 and K3 groups tended to increase. Increased body weight of mice began to occur at week 2, after the K1, K2, and K3 groups were given a high-fat diet. Levels of TC, LDL-C, and TG in K2 and K3 group treated with sweet peel leaf extract of Pacitan with a dosage of CMC-Na 1% dose 500 mg/kg BW and CMC-Na 1% dose 750 mg/kg BW Lower than the K1 group. Decreased levels of TC, LDL-C, and TG occurring in groups of K2 and K3 significantly. Conclusion: Administration of Pacitanese sweet orange peel extract with dose of CMC-Na 1% dose 500 mg/kg BW and CMC-Na 1% dose 750 mg/kg BW for six weeks on white male Wistar rats can significantly decrease total cholesterol, LDL-C, and TG but did not affect HDL-C levels