Abstract
BACKGROUND: In the literature, many beneficial effects are attributed ozone; it balances the oxidant-antioxidant system, leads to delivery of super enriched oxygen at a cellular level and optimizes cell function, etc. PURPOSE: The aim of this study was to evaluate if there is a positive impact of ozone therapy on bone healing in an experimental fracture model in rats. MATERIAL and METHODS: After approval of experimental animal ethic committee, an open femoral fracture (ffx) was performed in 48 male Spraque Dawley rats. They were randomly divided into two groups: in Group O, medical ozone/oxygen mixture (500 mg/kg) and in Group C, medical air in volume of 4 mL were given rectally for 3-days. At days 4, 7 and 13, eight rats from each group were euthanized, and histomorphometric and immunohistochemical bone tissue evaluation was undertaken from the femur sampling. RESULTS: Histomorphometrically, periost thickness was thicker, trabecular areas were larger, cartilaginous and new bone areas were smaller (p
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