Abstract
Oxytocin administered intravenously to the anaesthetized rat produced dilatation of the blood vessels of the cremaster muscle at concentrations ranging from 2.5 times 10-minus 11 to 2.5 times 10-minus 9 M. When applied topically to the exposed vessels it produced constriction at concentrations ranging from 2.5 times 10-minus 12 to 5.0 times 10-minus 8 M. Oxytocin was thus similar to adrenaline in eliciting opposite effects when applied to the serosa or to the intima of skeletal muscle blood vessels.
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