Abstract
The cure rate of spontaneous mammary adenocarcinomas in C3H mice irradiated daily while breathing air can be increased by changing to treatment twice a week or by allowing the mice to breathe pure oxygen at three atmospheres during treatment. Pure oxygen at atmospheric pressure is no more effective than air, probably due to depression of the respiratory rate by the oxygen. Oxygen at either pressure markedly increases systemic effects, as shown by early deaths. A mixture of 95 per cent oxygen and 5 per cent carbon dioxide at three atmospheres has about the same effect as pure oxygen at the same pressure on both cure rate and systemic effects. Only the gas mixture at atmospheric pressure gives the increased cure rate (because the respiratory stimulation and vasodilation resulting from the carbon dioxide carries more oxygen to the tumour) without increasing normal tissue reactions over those of air. It is, then, the technique of choice among those investigated.
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