Abstract
The effects of six different inspired oxygen concentrations on arterial (14 subjects) and mixed venous (8 subjects) pH, P CO 2 and P O 2 were measured. In all 14 subjects, o, CO 2 , minute ventilation, mean arterial blood pressure and heart rate were measured at each inspired concentration. Inspired O 2 concentrations between 21 and 40% produced a linear increase in arterial oxygen pressure and content and a progressive small rise in mixed venous oxygen content, with only minimal increase in mixed venous O 2 pressure and without change in O 2 , pH, P CO 2 , ventilation or cardiac output. With 100% O 2 the further rise in arterial P O 2 was accompanied by a significant increase in mixed venous oxygen pressure. The ventilation increased slightly; there was no change in cardiac output or acid-base balance.
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