The effect of Oxaliplatin in leading to apoptosis of intestinal cancer cells byinducing PUMA protein expression through reactive oxygen species

Abstract

Previous studies demonstrated Oxaliplatin, a drug used in treating intestinal cancers by inducing cancer cell apoptosisregulated by p53 upregulated modulator of apoptosis (PUMA) protein gene expression. Increasing the reactiveoxygen species (ROS) level is possible to speed up the expression of PUMA protein in Oxaliplatin. This study aimsto investigate the effect of Oxaliplatin in intestinal cancer cells, leading to its apoptosis by inducing PUMA proteinexpression through ROS, compared to Cisplatin and PBS. The result of the study will provide important insight into thepreclinical effectiveness of Oxaliplatin in intestinal cancer cells, and it also testifies to the underlying mechanism of thisdrug. Future studies should focus on investigating drug combinations with Oxaliplatin that provides synergism towardthe disease and decreases its toxicity.