The Effect of Oral Sulfonamide Diuretics on Carbohydrate Metabolism.

Abstract

s1 October 1964The Effect of Oral Sulfonamide Diuretics on Carbohydrate Metabolism.Stanley Green, M.D., F.A.C.P.Stanley Green, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-812_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe widespread use of oral sulfonamide diuretics has stimulated an increasing awareness of their metabolic side effects, namely, hyperglycemia, and hypokalemia. The mechanism of hyperglycemia has not been satisfactorily explained.Twenty-three well controlled diabetic patients were studied during a control period and for a prolonged period while on Chlorthalidone. The following data were collected: weight, blood pressure, blood sugar, serum potassium, uric acid, and urea nitrogen, 24-hr urinary 17-ketosteroids, 17-hydroxycorticosteroids, and aldosterone. During treatment approximately one half of the patients showed a significant rise in blood sugar and adrenal steroid excretion above control levels. The hyperglycemic response was inconsistent, occurring... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 812-812KeywordsBlood pressureBlood sugarCarbohydrate metabolismDiureticsExcretionHyperglycemiaPotassiumSulfonamideUreaUric acid Issue Published: 1 October 1964 PDF DownloadLoading ...