Abstract
The effect of the oral administration of oxyphenbutazone (Tandearil) on tumor growth and the levels of the seromucoid protein and seromucoid-bound carbohydrates of rats bearing Walker 256 has been studied. Oxyphenbutazone was administered at two dose levels, namely 60 mg/kg per day and 100 mg/kg per day. The anticipated elevation of seromucoid protein and seromucoid-bound carbohydrates was observed in untreated tumor-bearing rats. Oxyphenbutazone treatment suppressed the initial response of seromucoid protein and seromucoid-bound carbohydrate in tumor-bearing rats such that no significant elevation occurred over levels recorded for untreated nontumor-bearing rats for the first 8 days following transplantation. After 8 days the levels of seromucoid protein and seromucoid-bound carbohydrate were elevated in treated tumor-bearing animals as compared with untreated nontumor-bearing controls although the magnitude of the elevation was significantly less than that observed in untreated tumor-bearing animals.Oxyphenbutazone at an oral dose of 100 mg/kg per day proved toxic to the adult male rat. Toxicity was manifested by weight loss and occasionally by a fatal hemorrhagic gastritis.Tumors regressed in oxyphenbutazone-treated animals, and survival times of animals treated with oxyphenbutazone at 60 mg/kg per day exceeded those of comparable untreated tumor-bearing animals. In addition, treated animals were free of apparent malignant disease at the completion of the study.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have