The Effect of Oral Magnesium Supplements on Lipid Profile and Oxidative Stress in Adult Albino Female Rats

Abstract

The present study was designed to show the effect of magnesium on lipid profile and oxidative stress. The present study used 30 adult albino female rats that distributed to following groups (each group consist 6 rats); control group received ad libidium, second group administrated magnesium (orally, 35.7mg /kg) for eight weeks, third group administrated magnesium (orally, 71.4mg /kg) for eight weeks, fourth group (pregnant rats) administrated magnesium (orally, 35.7mg /kg) for eight weeks, fifth group (pregnant rats) administrated magnesium (orally, 71.4mg /kg) for eight weeks, and then killed. The results showed high significant increased (P < 0.05) in levels of lipid profile (total cholesterol, total glyceride, high density lipid (HDL), low density lipid (LDL) very low density lipid (VLDL)), especially in pregnant female rats (third and fifth groups) compared with control group. On the other hand, the results showed significant changes (P < 0.05) in levels of malondialdehyde (MDA), Superoxide dismutase (SOD) and catalase especially in pregnant female rats (third and fifth groups) compared with control group. It was concluded that the prolong using and overdose of magnesium lead to elevated the lipid profile and oxidative stress in rats especially in pregnant female rats.