Abstract
<p><em>H. pylori</em><strong> </strong>infection is one of the most common infections in the world so that the aim of this study was to evaluate the antimicrobial <em>P. Atlantica Kurdica</em> gum in the eradication of <em>H. pylori</em>. This study is a randomized clinical trial; Patients with positive Urea Breath Test and symptoms of dyspepsia were entered. Patients were randomly divided into four groups. Group A: three drugs including 500 mg of Amoxicillin twice a day (bd), Clarithromycin 500 mg bd and Omeprazole 20 mg (bd) and Group B: Group A drugs plus the capsule containing 1 g of powdered <em>P. Atlantica Kurdica </em>gum (bd). In Group C: the capsule containing 1 g of powdered <em>P. Atlantica Kurdica</em> gum (bd) and Group D: this group took placebo-containing capsule (bd) for 14 days respectively. Dyspeptic symptoms before and after healing period and the UBT results two days before the start of treatment and 30 days after the completion were compared in 4 groups. Patients were not statistically significant difference from each other in the four groups regarding the demographic situation. Moreover, <em>H. pylori</em> eradication rate was 19/24 in Group A, 18/24 in Group B, 10/23 in Group C and 2/24 in Group D. Relieving symptoms of dyspepsia in Groups B and C were significantly higher than in Group D (P=0.025 and p=0.006 respectively). <em>P. Atlantica Kurdica</em> significantly led to the treatment of dyspepsia symptoms and <em>H. pylori</em> eradication.</p>
Highlights
H. pylori are motile, non-spore-forming, curved or s-shaped gram-negative bacilli that their original position is human gastric mucosa (Shimomura et al, 2004)
In different regions of Iran, the prevalence of H. pylori in adults older than 35 years have been reported nearly 90% (Malekzadeh et al, 2000). It seems that the prevalence of H. pylori infection is declining in recent decades and is expected to decrease up to 25% in European countries (Magalhães Queiroz & Luzza, 2006), since H. pylori are the main cause of a wide range of gastric pathologies such as ulcer, gastric lymphoma, and adenocarcinoma, treating the infections caused by it are considered as a major problem (Ernst & Gold, 2000)
5 subjects who did not return for the second urea breathes test (UBT) were excluded from the study and 95 patients (45 men/50 women) with a mean who have age of 33 years were enrolled (Group A: 24 patients, Group B: 24 patients, Group C: patient and Group D: patients)
Summary
H. pylori are motile, non-spore-forming, curved (comma-shaped) or s-shaped gram-negative bacilli that their original position is human gastric mucosa (Shimomura et al, 2004). In different regions of Iran, the prevalence of H. pylori in adults older than 35 years have been reported nearly 90% (Malekzadeh et al, 2000). It seems that the prevalence of H. pylori infection is declining in recent decades and is expected to decrease up to 25% in European countries (Magalhães Queiroz & Luzza, 2006), since H. pylori are the main cause of a wide range of gastric pathologies such as ulcer, gastric lymphoma, and adenocarcinoma, treating the infections caused by it are considered as a major problem (Ernst & Gold, 2000). One is the side effects of www.ccsenet.org/gjhs
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