Abstract
Omega‐3 supplementation has been shown to be beneficial in reducing oxidative stress and inflammation. The purpose was to determine if 12 weeks of a high omega‐3 fatty acid diet would reduce age associated increases in myocardial oxidative stress and inflammation. 20 mature (M) (6 mo.) and 20 older (O) (15 mo.) SD rats were assigned to 2 diet groups: Control (CON) or Fish Oil (FO). Following the diet, animals were sacrificed and left ventricular heart tissue was harvested. Interleukin‐6 was significantly lower in MFO vs. OCON and OFO (26.58±0.67 vs. 37.77±3.85 & 37.68±2.23 pg/mg, respectively; p<0.05). Tumor necrosis factor‐alpha was not different among groups. Hydrogen peroxide production (H2O2) was reduced by FO treatment (p<0.01) but not significant in regards to age. However, OFO H2O2 trended towards significance vs. OCON (0.10±0.02 vs. 0.12±0.01 uM/mg ptn; p=0.09). A significant effect was seen for catalase with age (p<0.05), between MCON and OCON (3.04±0.38 vs. 4.49±0.36 U/mg ptn; p<0.05) and trended towards significance in OFO (3.04±0.38 vs. 4.25±0.36 U/mg ptn; p=0.1). There were no differences among groups for superoxide dismutase (p>0.05). These results suggest age‐associated increases in myocardial inflammation regardless of FO treatment. However, FO supplementation appears to increase some myocardial antioxidant activity and reduce H2O2.Supported by UD Research Foundation Grant
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