The effect of Omega-3 fatty acid on Adiponectin and potential implication for obesity management

Abstract

Objective: To evaluate the effect of 2 months use of omega-3 fatty acids on adiponectin and other parameters contribute to weight control in healthy obese volunteers like body mass index (BMI), waist and hip circumferences and to compare the concentrations of adiponectin between interventional groups and control groups. Design: Open–labeled randomized trial. Method: This study included seventy- eight volunteers, aged 20-55 years with different gender and BMI. The patients were divided into 2 groups, namely the omega-3 alone group which consisted of 25 obese subjects and the second one consisted of 26 obese subjects which represented the omega-3 and diet group. The subjects groups were followed for 2 months during which the above parameters were measured before starting therapy and at the end of the follow-up period using commercially available kits. The patient groups were compared with a control group consisted of 67 apparently healthy subjects. The determination of adiponectin concentration in human serum was done using ELISA technique Results: Significant differences were found regarding adiponecin (p=0.001) in the interventional groups in comparison with control group. The studied parameters were compared in the omega-3 groups and showed non-significant differences between the two studied groups concerning serum adiponectin (p=0.065). By comparing the studied parameters in the omega-3 alone group after 2 months of treatment, a significant differences were found in serum adiponectin (p=0.012). The use of omega-3 with diet for 2 months of treatment resulted in a significant increase in serum adiponectin (p=0.000). The percentage improvement in the studied parameters in the first group after 2 months of treatment showed highly significant increase in serum adiponectin (114.53%) with p-value (0.000). While in the second group, highly significant increase in serum adiponectin (214.10%) with p-value (0.000) were obtained. Conclusion: The level of Adiponectin was significantly increased in interventional groups compared to control. The level of Adiponectin was very significantly increased in omega-3 with diet group compared with omega-3 alone group which reflected on the improvement in anthropometric parameters such as weight and BMI. .