The effect of novel second generation prebiotics (levan of β‐[2,6]‐glycosidic linkages) on the cardiovascular system in obesity

Abstract

ObjectivesBacteria dysbiosis is very well documented in obesity and is known to regulate the cardiovascular system. Recovering the bacteria composition is a key element in improving the cardiovascular function during obesity.HypothesisIn this study we investigate the effect of levan, a novel second generation of prebiotic (β‐[2,6]‐linkages, on the cardiovascular system in obesity.MethodsEight‐week‐old C57/b6 mice were fed with high fat diet (HFD) for 12 weeks in the presence and absence of levan (β‐[2,6]‐linkages). Treatment was administered by gavage (250 mg/kg) for the last 30 days of HFD feeding. Body weight, blood glucose, body composition and lipid profile were determined. Vascular function and endothelial function markers were studied in aorta and mesenteric resistance arteries (MRA).ResultsLevan (β‐[2,6]‐linkages) treatment reduced the body weight in obese mice. Blood glucose, % of fat mass, total cholesterol, and LDL levels were significantly reduced and the % of lean mass was significantly increased after Levan (β‐[2,6]‐linkages) treatment. Aortic and mesenteric arteries vascular response to sodium nitroprusside (SNP) was similar among groups. However, the vascular response to acetylcholine (Ach) was improved in the treated group.ConclusionsTreatment with Levan (β‐[2,6]‐linkages) attenuated the increase in body weight in obese mice and restored the lipid profile and the vascular function.