The effect of normobaric hypoxia on the level of organ-specific and organ-specific antibodies in individuals with thyroid diseases

Abstract

Time course of organ-nonspecific and organ-specific antibodies during normobaric interval hypoxic training (IHT) is followed up in 25 normal subjects and 34 patients with thyroid diseases in a state of euthyrosis. Hypoxic test was carried out in all examinees before and after IHT. IHT was performed in individual regimens of inhalations of hypoxic gas mixture and ambient air alternatively. The initial titers of antibodies to different organs and tissues were higher in the patients than in normal subjects. According to hemodynamic parameters, the tolerance of hypoxia improved after adaptation of patients to normobaric hypoxia. The euthyrosis status did not change. Antibody titers significantly decreased after IHT both in the patients and normal subjects. IHT had a positive effect on the humoral immunity. IHT is recommended for patients with thyroid diseases to be used in complex with other methods of treatment.