Abstract
Rats were nephrectomized (Nx) or sham-operated (S) at the age of 5, 12 and 40 days. One group of rats was Nx in utero 3-4 days before delivery. Light microscopy studies of renal structural development were carried out in the postnatal Nx and S rats at the age of 6-26 days. Renal structural development followed the same pattern in Nx as in S rats. The formation of new nephrons was completed at the age of 6-7 days. There was no structural evidence of formation of new nephrons. Furthermore, glomerular counting showed the same number of glomeruli in Nx and S rats at the age of 60 days. The number of glomeruli in fetal nephrectomized rats was the same as in control animals from the same litter. GFR, SNGFR and kidney weight were estimated at 60 days of age in Nx and S rats. The compensatory increase in renal weight and GFR was most pronounced in rats Nx at the age of 5 days, i.e. just before the formation of nephrons was completed.The quotient between the recorded SNGFR and GFR was the same in all groups studied, indicating a homogenous increase in SNGFR of the nephrons at all cortical levels.
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