The Effect of Norbactin on the Lipid Profile of the Cardiovascular System of Albino Rats

Abstract

Antibiotics have been reported to produce varied degree of toxicity to different organs and systems. Thus, the present study investigated the effect of Norbactin on the lipid profile of the cardiovascular system of Albino rats. The research was performed on 20 adult male Albino rats, randomly placed in 5 groups (A,B,C,D,E) of 4 rats in each. Group A,B,C,D were administrated 5.72,11.43,17.15 and 22.86(mg/kg) respectively of Norbactin solution. Group E was the control. The administration was by oral intubation and lasted for 7 consecutive days. Physical activities, feed and water intake was found to decrease in the test groups while the control did not show significant (p>0.05) changes. Concentration of total cholesterol, triglyceride and low density lipoprotein in the groups administered the drug was significantly (p>0.05) higher than the control. The level of high density lipoprotein recorded in group A,B,C and D was significantly (p<0.05) lower than in the control. This effect were found to be dose dependent. The findings of this study suggest that Norbactin may be toxic to the cardiovascular system. It may not be suitable for a patient with cardiovascular disorders.