Abstract
The effect of N 2O-induced vitamin B 12 deficiency on in vivo folate metabolism was studied in an animal model previously developed for studies of the folate enterohepatic cycle, and in rats with localized, subcutaneous tumor nodules. While N 2O inhibited liver folate polyglutamate formation, it did not affect the absorption of ( 3H)PteGlu 1 from the gut, its reduction, methylation, and transport to the liver, or the subsequent secretion of CH 3H 4( 3H)PteGlu 1 into bile—the folate enterohepatic cyle. In addition, N 2O did not impair folate polyglutamate formation in the fibrosarcoma tumor nodule suggesting that tumor tissue can either demethylate CH 3H 4PteGlu 1 by an alternate pathway or can utilize it as a substrate for polyglutamate formation without demethylation.
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