Abstract
Objective: In PD, dopaminergic neurons in the SNc degenerate, followed by secondary dendritic pruning in the striatum which induces the motor symptoms rigidity, tremor, and bradykinesia. Therapeutic options by substituting lacking dopamine improve clincial symptoms. However, in advanced stages, patients often experience dyskinesia and motor fluctuations due to the progressive loss of spines. Morphological changes of MSN in the striatum can therefore represent a therapeutic target. Yet, it has not been resolved whether the changes in MSN morphology are reversible or irreversible. Therefore, we exploited in this study the spontaneous regeneration of dopaminergic axon terminals in the striatum and determined MSN morphology (a) early after degeneration and in addition (b) 3 months later when axon terminals had recovered.
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