Abstract
Aims: To find out the effect of topical Nigella Sativa oil on healing of chemically induced oral ulcer. Materials and Methods: Twelve rabbits were used and divided into control and treated groups, the ulcers were induced by injection of 0.3 ml 1%formalin in rabbit cheek mucosa and were treated by daily application of black cumin (N.S) twice on the ulcer site for 3days then the animals were sacri-ficed 5days later. Results: Nigella Sativa (N.S) showed marked anti inflammatory activity on a chemi-cally induced oral ulcer in experimental animals ,histological examination of biopsies from ulcers after three days of treatment revealed difference in the rate of epithelization and healing process of ulcers between the two groups, N.S treatment showed significant enhancement of healing of the ulcers. Con-clusions: Nigella Sativa oil has an obvious effect on the rate of healing process of oral ulcer.
Highlights
Recurrent Aphthous ulceration (R.A.U) or recurrent A
Stomatitisis the most common oral mucosal disease known to human beings, despite much clinical and research attention[1] An aphthous ulcer is a type of oral ulcer which presents as a painful open sore inside the mouth or upper throat, caused by a break in the mucous membrane
After 24 hours following the injection, the animals were examined by measuring the site of the induced ulcer using calibrated probe and signs of inflammation were present, daily application of N.S oil on ulcer sites for 3 days, the animals sacrificed five day later and the tissue fixed in buffered formalin 10%, prepared for histopathological examination under light microscopic. microscopic examination of H&E stained sections of 5 microns thickness from ulcers revealed difference in the rate of epithelization and healing process of ulcer between treated and control group
Summary
Recurrent Aphthous ulceration (R.A.U) or recurrent A. RAU occur exclusively on non-keratinized, movable mucosa, such as buccal (cheeks) and lingual mucosa, the floor of the mouth, and the soft palate It is characterized as a yellow-gray ulcer surrounded by an erythematous halo less than 10 mm in diameter. They occur on moveable nonkeratinizing oral surfaces, but the ulcer borders may extend onto keratinized surfaces. Cessation of smoking: This may precipitate or exacerbate RAS in some cases
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