Abstract
The use of tobacco is still rising globally especially between teenagers. Therefore, the effects of early administration of nicotine on the liver and kidney were studied. Forty pre‐pubertal male Sprague Dawley albino rats 4 weeks age weighing 40–65 grams were divided into 4 groups, each of 10 rats. Control groups G1 and G 3 were injected with saline for 1 & 2 weeks respectively, G2 and G4 were injected with nicotine (6.25ng/g) for 1 & 2 weeks respectively. All groups were injected intraperitoneally. Histological studies of the liver showed deleterious effects of nicotine on both liver and kidney in G4. ALT level showed a significant increase (P=0.01) in G4, where a significant increase in AST (P=0.01) was found in both G2 and G4. Urea showed a significant increase (P=0.01) in G4. Lipids however, showed a significant decrease in cholesterol (P=0.01) and HDL‐C (P=0.001) in both G2 and G4, while triglyceride level significantly increased (P<0.05) in G4. X‐ray microanalysis studies showed a significant increase in sodium (P=0.001) in the liver in G4, while magnesium showed a significant decrease (P=0.01) in the kidney in G4. A significant increase in IL‐2 (P<0.05) in both G2 and G4 was detected. However, IL‐6 showed a significant increase (P=0.01) in G4. These results indicate that nicotine exposure increase the risk of damage that occurs in the liver and kidney with increasing the period of exposure to nicotine.
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