Abstract
To evaluate the acute effects of nicotine on macular microvasculature by optical coherence tomography angiography (OCTA). Non-smokers who were administered 4 mg nicotine gum (study group) or placebo gum (control group) were enrolled, 18 individuals in each group. All participants underwent OCTA at baseline and 1 hour after gum chewing. Macular flow area, macular vessel density, foveal avascular zone area, central foveal thickness, and subfoveal choroidal thickness were analyzed. Macular flow area, vessel density, and subfoveal choroidal thickness decreased in the nicotine group (P < .05). No statistically significant difference observed in central foveal thickness, when compared with baseline measurement (P > .05). Nicotine causes a significant decrease in macular microcirculation. Deterioration of macular microcirculation can be quantitatively detected by OCTA noninvasively. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:691-700.].
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