Abstract
Forty-eight male guinea pigs on an ascorbic acid free diet received daily oral injections of 2 mg L-ascorbic acid/100 g body weight for 2 weeks. Simultaneous injections of nicotine were given subcutaneously at 0.66 mg per animal per day; during the second week a second nicotine dose was administered 3 h later. On an equal weight basis each injection was approximately double the nicotine intake of a smoker of 40 cigarettes per day. On the last day at 1 h after a dose of L-ascorbic acid-1-14C there was more radioactivity and ascorbic acid remaining in the gastrointestinal tract contents of nicotine-treated animals than in saline-injected control animals. There were lower concentrations of L-ascorbic acid-1-14C in adrenals, brain, kidneys, and liver of nicotine-injected animals 1 h after the dose but higher concentrations 3, 6, and 12 h after the dose when compared to saline-injected animals. At all times adrenal and liver total ascorbic acid concentrations were higher in nicotine-treated animals. Brain and kidney concentrations showed a similar trend. The results indicate that there was delayed absorption of ascorbic acid in the presence of nicotine. Possible mechanisms of this effect are considered.
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