Abstract
Cytotoxicity was compared between new root canal sealers (New A, New B, and New B-2) and conventional root canal sealers (AH26, Diaket, Canals, Tubi-Seal, and Sealapex). Dental pulp cells of rats, obtained through primary cell culture, were used. In the experiments with the freshly prepared sealers, the incorporation of [3H]thymidine into cellular DNA was analyzed. In the experiments with the set sealers, the morphological changes of cells were microscopically examined. In the experiments with the fresh sealers, AH26 and Diaket showed strong inhibitive effects on the DNA synthesis, whereas no such effects were noted with the new sealers and Sealapex. On the other hand, in the experiments with the set sealers, the new sealers and Diaket exerted little influence on the cells. However, other sealers had considerable toxicity. These results suggest that the new sealers were the least toxic in vitro, compared with five conventional sealers.
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