The Effect of New Haemostatic Agent Ostene® on Bone Healing (A Comparative Experimental Study)

Abstract

ABSTRACT Introduction: Ostene ® is a bone wax-like preparation of water-soluble wax (WSW). It is an alkylene oxide copolymers mechanical haemostatic agent. This study aims to evaluate the effects of Ostene ® on bone healing. Materials and Methods: Twenty albino rabbits were randomized into three groups according to study materials into [Ostene, gelfoam, control (no material applied)]. Each group was subdivided into 4 groups according to healing periods (24h., 3days, 7days, 14 days). Three holes were made in mandible of each rabbit. Two holes were made on one side and third hole on the other side of mandible using 5mm surgical bur. Finally, the incision was closed. The specimens were collected and examined histopathologicaly. Result and Discussion: This study showed that there is a significant difference between ostene group and other groups in which P -value was ≤ 0.05. During 24h of healing, there is a significant difference in osteoblast cell formation in which P -value was 0.03 and osteoclast cell formation P -value was 0.05. New blood vessel formation, osteoblast and osteoclast cell formation for ostene group during 3days of healing P -value was 0.05, 0.03, 0.04 respectively .In 7days of healing P -value was 0.05 for osteoblast cell and 0.04 for osteoclast cell. In 14 days of healing P -value of ostene in osteoblast cell formation was 0.05 and osteoclast cell formation was 0.04. Conclusions: Ostene bone haemostatic agent is an effective agent that enhances osteogenesis by initiating proliferation of osteoblast and osteoclast cells.