Abstract
Background: Alzheimer’s disease (AD) is pathologically characterized by extracellular deposits of β-amyloid (Aβ) and intracellular accumulation of hyper-phosphorylated tau. Previous brain imaging studies have shown that the accumulation of Aβ appears mainly in brain regions where neuronal activity is increased in the early stage of AD. It has been reported that Aβ production is enhanced by neuronal activation in vivo. However, it remains controversial whether neuronal activity facilitates Aβ production or not in vitro.
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