Abstract
BackgroundA double blind, randomized, placebo controlled study to evaluate the safety and efficacy of the naturally derived topical oil, "Neuragen PN®" for the treatment of neuropathic pain.MethodsSixty participants with plantar cutaneous (foot sole) pain due to all cause peripheral neuropathy were recruited from the community. Each subject was randomly assigned to receive one of two treatments (Neuragen PN® or placebo) per week in a crossover design. The primary outcome measure was acute spontaneous pain level as reported on a visual analog scale.ResultsThere was an overall pain reduction for both treatments from pre to post application. As compared to the placebo, Neuragen PN® led to significantly (p < .05) greater pain reduction. Fifty six of sixty subjects (93.3%) receiving Neuragen PN® reported pain reduction within 30 minutes. This reduction within 30 minutes occurred in only twenty one of sixty (35.0%) subjects receiving the placebo. In a break out analysis of the diabetic only subgroup, 94% of subjects in the Neuragen PN® group achieved pain reduction within 30 minutes vs 11.0% of the placebo group. No adverse events were observed.ConclusionsThis randomized, placebo controlled, clinical trial with crossover design revealed that the naturally derived oil, Neuragen PN®, provided significant relief from neuropathic pain in an all cause neuropathy group. Participants with diabetes within this group experienced similar pain relief.Trial registrationISRCTN registered: ISRCTN13226601
Highlights
A double blind, randomized, placebo controlled study to evaluate the safety and efficacy of the naturally derived topical oil, "Neuragen PN®" for the treatment of neuropathic pain
Homeopathic substances are often delivered as single agents, there are a number of clinical studies that have employed a combination of homeopathic substances within one product for various disorders [7,8,9,10]
Participants Individuals with physician diagnosed peripheral neuropathy and pain levels greater than 3 but no higher than 8 were recruited through existing University databases, community support groups, and advertisements placed in community newsletters and newspapers
Summary
A double blind, randomized, placebo controlled study to evaluate the safety and efficacy of the naturally derived topical oil, "Neuragen PN®" for the treatment of neuropathic pain. John's Wort (Hypericum perforatum), Wolfsbane (Aconitum napellus), Club Moss (Lycopodium clavatum), phosphorus, Poison Ivy (Rhus toxicodendron) and Rye ergot (Secale cornutum) Their potencies are all 12C, and all six of these substances have a record of traditional use for nerve related pain (Homeopathic reperatories list them as moderately or strongly recommended for: Generalities, Injuries, nerves; Generalities, Pain, burning or shooting) [6]. The five essential oils in Neuragen PN®, a proprietary blend of geranium oil (Pelargonium graveolens), lavender oil (Lavandula angustifolia), bergamot oil (Citrus aurantium), tea tree oil (Melaleuca alternifolia) and eucalyptus oil (Eucalyptus globulus), act as transdermal carriers These carriers are believed to assist in the penetration of the homeopathic ingredients through the stratum corneum of the skin [11,12]
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