Abstract
The effects of different doses of neostigmine methylsulfate, atropine sulfate and ephedrine on the heart rate in fit volunteers were studied. Neostigmine decreased heart rate equally in unmedicated subjects and in subjects premedicated with 25 mg. ephedrine, but decreased the rate much more in subjects premedicated with 0.6 to 1.5 mg. atropine sulfate. Under the experimental conditions, from sevenfold to twentyfold doses of atropine sulfate were required to block completely the effect of neostigmine methylsulfate on heart rate. About twice the weight of atropine sulfate was required to prevent neostigmine methylsulfate from lowering heart rates below base line. The effect of neostigmine on heart rate began within a minute after intravenous injection, reached a maximum in about 20 minutes, and lasted for more than an hour.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
