Abstract
Objective: This study aimed to assess the effect of Nelumbo nucifera alcoholic extract (LLAE) on the intestinal microbiota in high-fat diet-induced hyperlipidemia. Methods: Thirty male-specific pathogen-free Sprague–Dawley rats were randomly divided into 3 groups: the blank control group, the model control group, and the LLAE group. The body weight of the rats was recorded during the treatment period. The serum, liver, and intestinal content samples were collected for further analysis after sacrificing. Results: The results suggest that LLAE-treated hyperlipidemic rats showed a significant reduction in serum triglycerides, total cholesterols, and low-density lipoprotein cholesterol levels. LLAE could improve hepatocyte steatosis and ameliorate hepatocyte injury. The significant variation in gut microbial alpha diversity at multiple levels, including phylum and genus levels occurred throughout treatment in the LLAE group. The intestinal microbiota of hyperlipidemic rats were disordered, and there was a correlation between the amount of intestinal flora and the level of lipids. Conclusion: LLAE may improve hepatocyte function by changing the type and abundance value of intestinal microorganisms, reducing the content of total cholesterol, total triglyceride, and low-density lipoprotein cholesterol, and thus improving hyperlipidemia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
