Abstract
Background: To evaluate the effect of nebulized salbutamol used in the management of patients with asthma who have normal serum potassium and blood glucose levels.
 Methods: Hospital based prospective study conducted on 30 children mild exacerbation of asthma who needed two doses of 2.5 mg nebulized salbutamol, 10 minutes apart for the relief of their symptoms will be include.
 Results: The potassium mean was significantly decreased after 1 hour of nebulizer administration. The random blood sugar mean was significantly increased after 1 hour of nebulizer administration (p<0.001).
 Conclusions: The nebulizer applying salbutamol has a profound effect in lowering the Potassium level and increasing blood glucose level after 60 minutes of administration.
 Keywords: effect, nebulized, salbutamol, blood sugar, serum potassium
Highlights
Nebulizers are inhalation devices that use oxygen, compressed air, or ultrasonic power to break up solutions or suspensions of medication into droplets for inhalation
Background: To evaluate the effect of nebulized salbutamol used in the management of patients with asthma who have normal serum potassium and blood glucose levels
The potassium mean was significantly decreased after 1 hour of nebulizer administration
Summary
Nebulizers are inhalation devices that use oxygen, compressed air, or ultrasonic power to break up solutions or suspensions of medication into droplets for inhalation. Β2AR stimulation of the Na+ /K+ -ATPase pump increases intracellular concentrations of potassium and hyperpolarization of the cellular membrane. The activation of this pump consumes ATP, leading to ADP production that further drives glycolysis, resulting in increased lactate production (Andersson et al, 2012; Kalsen et al, 2014; Levy et al, 2008). The β2AR agonists increase glycogenolysis and increase plasma glucose. This is of minor clinical importance, except in diabetic patients, whose disease is likely to be aggravated by the use of systemic corticosteroids in situations of severe asthma. The effect on glucose shows tolerance with repeated use 4
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