Abstract
Introduction: Polycystic ovary syndrome is one of the important syndromes which is caused by endocrine disorder with a prevalence in the range of 5–21% among female during the reproductive-aged worldwide. Aim: assessment of n-butanol fraction of Cressa cretica plant effect on steroids and gonadotropin hormones and ovary morphology of rat PCOS-model. Materials and methods: 18 female rats were divided into 3 groups each group with 6 rats. Control group treated with vehicle propylene glycol for 30 days S.C while PCOS-model and n-butanol groups treated with testosterone propionate 10mg/kg/day for 30 days S.C. After, n-butanol fraction of Cressa cretica extract was given to n-butanol group 100mg/kg/ day for 35 days while the control and PCOS-model were given propylene glycol orally for 35 days. Steroid and gonadotropin hormones were assessed, ovary morphology and preliminary analysis for n-butanol fraction was also conducted. Results: n-butanol group shows an apparent reduction of testosterone and significant reduction in LH hormone and restore ovary morphology. Conclusion: n-butanol fraction of Cressa cretica plant can be considered a potential therapeutic agent for PCOS in female.
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