Abstract
Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products. Objective This systematic review aims to summarize the natural products used in treatment of experimental models of TMD.Methodology A systematic search was performed in the databases Medline, Web of Science, Scopus, Embase, SciELO, LILACS, and Scholar Google databases in January 2020, dating from their inception. Pre-clinical studies with natural products for intervention in experimental TMD were included. Two reviewers independently selected the studies, extracted the data, and evaluated the risk of bias.Results 17 records were selected, and 17 different natural products were found, including three lectins, three plants or algae extracts, three sulfated polysaccharides, three cocoa preparations, and five isolated compounds. Concerning the risk of bias, most studies lacked on randomization and blinding. Nociception induced by phlogistic agents was evaluated in most articles, and in five studies it was associated with analysis of inflammatory parameters. In order to investigate the mechanism of action of the natural products used, eight studies evaluated expression of neural or glial molecular markers.Conclusions 16 of 17 natural products found in this review presented positive results, showing their potential for treatment of TMD. However, the lack of methodological clarity can influence these results.
Highlights
The effect of natural products in animal models of temporomandibular disorders models of TMD.Te mporomandibulardisorders ( T M D ) are multifactorial disorders that impair the temporomandibular joint, muscles of mastication, and muscle innervation of head and neck.1,2 These disorders approximately affect 5% of the population with a prevalence between 7.3% and 30.4% in the young people population and it can greatly affect the patients’ quality of life.1,3 The symptoms vary from mild discomfort to debilitating pain.1,3The treatment of TMD is initially composed of the reduction of pain and debilitation, which can be achieved by several interventions with multidisciplinary approach
Considering the need for new pharmacological alternatives to treat TMD, this study reviewed the use of different natural products (NP), essentially plant preparations or compounds isolated from plants, in pre-clinical studies involving animals submitted to models of TMD, to answer which NP have already been investigated for the treatment of experimental
The classification of Research Diagnostic Criteria for TMD is divided into four groups,29 in this review, natural products were only tested in models of temporomandibular joint (TMJ) disorders and in masticatory muscle disorders
Summary
The effect of natural products in animal models of temporomandibular disorders models of TMD.Te mporomandibulardisorders ( T M D ) are multifactorial disorders that impair the temporomandibular joint, muscles of mastication, and muscle innervation of head and neck. These disorders approximately affect 5% of the population with a prevalence between 7.3% and 30.4% in the young people population and it can greatly affect the patients’ quality of life. The symptoms vary from mild discomfort to debilitating pain.1,3The treatment of TMD is initially composed of the reduction of pain and debilitation, which can be achieved by several interventions with multidisciplinary approach. Te mporomandibulardisorders ( T M D ) are multifactorial disorders that impair the temporomandibular joint, muscles of mastication, and muscle innervation of head and neck.. Te mporomandibulardisorders ( T M D ) are multifactorial disorders that impair the temporomandibular joint, muscles of mastication, and muscle innervation of head and neck.1,2 These disorders approximately affect 5% of the population with a prevalence between 7.3% and 30.4% in the young people population and it can greatly affect the patients’ quality of life.. The treatment of TMD is initially composed of the reduction of pain and debilitation, which can be achieved by several interventions with multidisciplinary approach. Conservative intervention includes patient education, physiotherapy, psychosocial management, occlusal splints and medicine. The association of these approaches is common in clinical practice.. The association of these approaches is common in clinical practice. Generally, pharmacological approach, by itself or associated with other approaches still the main clinical approach. the effectiveness of the available medicines for TMD is questionable and their side effects can limit their clinical use. other alternatives have been investigated, such as natural products (NP)
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