Abstract
Naringenin (4′,5,7-trihydroxy-flavanone) inhibits the accumulation of glycine, β-methyl-glucoside, p-amino-hippurate and N1-methyl-nicotinamide in dog renal cortex slices. It also inhibits oxygen consumption by this tissue. Since the sensitivity of amino-acid uptake to the drug is less than the sensitivity of oxygen consumption, the inhibition of this transport might be secondary to an effect on intermediary metabolism. The inhibition of PAH uptake occurs at a lower concentration of the drug, and so naringenin may affect this process at the membrane level.
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