The effect of nalbuphine, sufentanil, and ropivacaine in multimodal analgesia after gynecological single-hole laparoscopic surgery

Abstract

Objective To observe the analgesic effect of local infiltration multimodal analgesia with nalbuphine, sufentanil, and ropivacaine in gynecological single-hole laparoscopic surgery. Methods A total of 104 patients who were treated with gynecological single-hole laparoscopic surgery under intravenous combined anesthesia were divided into group A and B according to the complete random grouping method, 52 cases in each group. Group A was given postoperative patient controlled intravenous analgesia (PCIA) with 48 hours of continuous pump injection with sufentanil 0.04μg/(kg•h); group B was given local infiltration around the incision with 10 ml of 0.5% ropivaeaine before the wound was sutured, and postoperative PCIA with 48 hours of continuous pump injection with sufentanil 0.03μg/(kg•h) and nalbuphine 15μg/(kg•h). Observed the analgesic, sedation and comfort scores of gynecological patients in the period of 0-2 h, 2-6 h, 6-12 h, 12-24 h, and 24-48 h after laparoscopic surgery, the incidence of analgesic adverse events within 48 h after laparoscopic surgery in the two groups, the times of self-control compressions, and the comfortable satisfaction degree of the incision site of single-hole laparoscopic surgery. Results The times of self-control compressions at each time period within 12 h after laparoscopic surgery in group B were significantly less than those in group A (P<0.05). The VAS analgesia score of group B at 2 h and 6 h after exiting the recovery room were significantly lower than those of group A (P<0.05). The BCS comfort score of group B was significantly higher than that of group A at each time point after exiting the recovery room (P<0.05). The comfortable satisfaction degree of the incision site of single-hole laparoscopic surgery of group B was significantly better than that of group A (P<0.05). The incidence of analgesic nausea and vomiting of group B was significantly lower than that of group A (P<0.05). Conclusions The multimodal analgesia with nalbuphine, sufentanil, and ropivacaine local infiltration can significantly improve the analgesic effect after gynecological single-hole laparoscopic surgery, reduce adverse reactions, enhance comfort degree of the incision site of single-hole laparoscopic surgery, which provides a new idea for the rapid recovery of specific patients. Key words: Nalbuphine; Sufentanil; Ropivacaine; Single-hole laparoscopic surgery; Multimodal analgesia