Abstract
A green method, using pulsed spark discharge (PSD) to synthesize colloidal gold, is studied in this thesis. PSD uses spark discharge to synthesize gold nanoparticles (AuNPs) in deionized water (DIW) and/or ethanol (EtOH). While gold nanoparticles have widespread applications in many fields, especially for the human body, in use them must overcome the influence of NaCl and pH value; therefore, this study adds NaCl into PSD-AuNPs to simulate the human body to study its stability. Furthermore, a variety of protectants are added in an attempt to determine the best protectant for AuNPs and improve biologically compatible potency. From the results of this study, adding the long-chain-polymer Carboxymethyl cellulose (CMC) or Polyvinyl pyrrolidone (PVP-k30) can prevent nanogold from aggregation and precipitation in NaCl or different pH value and maintain the characteristic of nanogold dispersion by raising the repulsive force between the particles. The results of this study can be a reference of nanogold applying in biomedical science.
Highlights
The pulse spark discharge (PSD) method is developed and used to fabricate the AuNPs solution [1,2,3,4,5], which involves a pulse current being passed through two gold electrodes [6,7,8], which are submerged in deionized water or ethanol
Gold nanoparticles fabricated by the pulse spark discharge (PSD) method in deionized water or ethanol without any surfactants or stabilizers are characterized as a stable colloid, which can be stored for a long term in a glass container at room temperature without visible sedimentation
This study proposes an effective gold number method in order to determine the gold number of potential colloidal gold stabilizers
Summary
The pulse spark discharge (PSD) method is developed and used to fabricate the AuNPs solution [1,2,3,4,5], which involves a pulse current being passed through two gold electrodes [6,7,8], which are submerged in deionized water or ethanol. Many methods of producing AuNPs include the introduction of surfactants in order to improve the suspension of the gold particles. Gold nanoparticles fabricated by the pulse spark discharge (PSD) method in deionized water or ethanol without any surfactants or stabilizers are characterized as a stable colloid, which can be stored for a long term in a glass container at room temperature without visible sedimentation (no apparent precipitate). The DIW nanogold is safe for the human body, such as target therapy and drug carriers; this study will propose the experiments and simulate results of the colloidal gold [9,10,11,12,13] within the NaCl and pH test. This study simulates the human body or normal saline in NaCl in order to discuss the impacts on gold nanoparticles of DIW nanogold, under various biologically compatible protective agents, for improving biologically compatible potency. The impacts on, and variations in, suspension of pH value of gold nanoparticles (DIW nanogold, chem. nanogold, and ethanol nanogold) fabricated by other methods, as well as the changes of absorbance and wavelength, are compared
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